| Scenerync | Дата: Вторник, 02.04.2013, 15:41:22 | Сообщение # 1 |
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A 2001 study concluded that nitrofurantoin is actively transported into milk by an unknown mechanism, resulting in a milk:plasma (m:p) ratio of 6.21 ± 2.71 (14). the observed m:p ratio was about 22-fold greater then the predicted ratio (0.28) that was determined in the study. four lactating women, who did not breast feed during the study, were given a single 100-mg capsule of nitrofurantoin macrocrystals with a standardized high-fat breakfast. nine serum and milk samples were drawn after the dose over a 12-hour interval. the mean milk drug concentration in each patient during the 12-hour interval was approximately 1.3 µg/ml. based on this, the investigators estimated that, if a 60-kg woman was taking 100 mg twice daily, the infant dose would be 0.2 mg/kg, or about 6% of the mother's weight-adjusted dose. although this exposure was thought to be low, the authors concluded that nursing infants younger than 1 month of age and those with a high frequency of g-6-pd deficiency or sensitivity to nitrofurantoin may be at risk for toxicity (14).
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If you stopped taking duricef, at least for 24 hours, i see no problem in starting now with flygyl. but if you are worried perhaps calling your doctor is better.
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If you are pregnant or think that you might be, it's best not to take any sort of medication at all. i would try talking to your doctor just to be on the safe side.
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